diff --git a/.devcontainer/on-create-command.sh b/.devcontainer/on-create-command.sh
index deffa37b..fdf77952 100755
--- a/.devcontainer/on-create-command.sh
+++ b/.devcontainer/on-create-command.sh
@@ -3,7 +3,7 @@ set -e
 
 python3 -m venv .venv
 . .venv/bin/activate
-pip install -U pip setuptools wheel
+pip install -U pip
 pip install -r requirements/dev.txt
 pip install -e .
 pre-commit install --install-hooks
diff --git a/CHANGES.rst b/CHANGES.rst
index 482d9a18..3264a25e 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -309,7 +309,7 @@ Released 2022-03-28
     or ``AppContext.g`` instead. :issue:`3898`
 -   ``copy_current_request_context`` can decorate async functions.
     :pr:`4303`
--   The CLI uses ``importlib.metadata`` instead of ``setuptools`` to
+-   The CLI uses ``importlib.metadata`` instead of ``pkg_resources`` to
     load command entry points. :issue:`4419`
 -   Overriding ``FlaskClient.open`` will not cause an error on redirect.
     :issue:`3396`
diff --git a/CONTRIBUTING.rst b/CONTRIBUTING.rst
index 24daa729..fed44978 100644
--- a/CONTRIBUTING.rst
+++ b/CONTRIBUTING.rst
@@ -127,7 +127,7 @@ First time setup in your local environment
 
     .. code-block:: text
 
-        $ python -m pip install -U pip setuptools wheel
+        $ python -m pip install -U pip
         $ pip install -r requirements/dev.txt && pip install -e .
 
 -   Install the pre-commit hooks.
diff --git a/docs/patterns/packages.rst b/docs/patterns/packages.rst
index 239a3fa2..90fa8a8f 100644
--- a/docs/patterns/packages.rst
+++ b/docs/patterns/packages.rst
@@ -54,8 +54,8 @@ a big problem, just add a new file called :file:`pyproject.toml` next to the inn
     ]
 
     [build-system]
-    requires = ["setuptools"]
-    build-backend = "setuptools.build_meta"
+    requires = ["flit_core<4"]
+    build-backend = "flit_core.buildapi"
 
 Install your application so it is importable:
 
diff --git a/docs/tutorial/install.rst b/docs/tutorial/install.rst
index 9bb1234e..519b0678 100644
--- a/docs/tutorial/install.rst
+++ b/docs/tutorial/install.rst
@@ -40,30 +40,13 @@ The ``pyproject.toml`` file describes your project and how to build it.
     ]
 
     [build-system]
-    requires = ["setuptools"]
-    build-backend = "setuptools.build_meta"
+    requires = ["flit_core<4"]
+    build-backend = "flit_core.buildapi"
 
-
-The setuptools build backend needs another file named ``MANIFEST.in`` to tell it about
-non-Python files to include.
-
-.. code-block:: none
-    :caption: ``MANIFEST.in``
-
-    include flaskr/schema.sql
-    graft flaskr/static
-    graft flaskr/templates
-    global-exclude *.pyc
-
-This tells the build to copy everything in the ``static`` and ``templates`` directories,
-and the ``schema.sql`` file, but to exclude all bytecode files.
-
-See the official `Packaging tutorial <packaging tutorial_>`_ and
-`detailed guide <packaging guide_>`_ for more explanation of the files
-and options used.
+See the official `Packaging tutorial <packaging tutorial_>`_ for more
+explanation of the files and options used.
 
 .. _packaging tutorial: https://packaging.python.org/tutorials/packaging-projects/
-.. _packaging guide: https://packaging.python.org/guides/distributing-packages-using-setuptools/
 
 
 Install the Project
@@ -95,9 +78,7 @@ You can observe that the project is now installed with ``pip list``.
     Jinja2         2.10
     MarkupSafe     1.0
     pip            9.0.3
-    setuptools     39.0.1
     Werkzeug       0.14.1
-    wheel          0.30.0
 
 Nothing changes from how you've been running your project so far.
 ``--app`` is still set to ``flaskr`` and ``flask run`` still runs
diff --git a/requirements/typing.in b/requirements/typing.in
index 2c589ea0..d2313079 100644
--- a/requirements/typing.in
+++ b/requirements/typing.in
@@ -1,5 +1,4 @@
 mypy
 types-contextvars
 types-dataclasses
-types-setuptools
 cryptography
diff --git a/requirements/typing.txt b/requirements/typing.txt
index ede79887..bad6fb22 100644
--- a/requirements/typing.txt
+++ b/requirements/typing.txt
@@ -1,4 +1,4 @@
-# SHA1:7cc3f64d4e78db89d81680ac81503d5ac35d31a9
+# SHA1:6a354b832686fd3ec017455769a0270953a1e225
 #
 # This file is autogenerated by pip-compile-multi
 # To update, run:
@@ -19,7 +19,5 @@ types-contextvars==2.4.7.2
     # via -r requirements/typing.in
 types-dataclasses==0.6.6
     # via -r requirements/typing.in
-types-setuptools==68.0.0.0
-    # via -r requirements/typing.in
 typing-extensions==4.6.3
     # via mypy