diff --git a/spring-orm/src/main/java/org/springframework/orm/jpa/EntityManagerRuntimeHints.java b/spring-orm/src/main/java/org/springframework/orm/jpa/EntityManagerRuntimeHints.java
new file mode 100644
index 00000000000..97161871387
--- /dev/null
+++ b/spring-orm/src/main/java/org/springframework/orm/jpa/EntityManagerRuntimeHints.java
@@ -0,0 +1,44 @@
+/*
+ * Copyright 2002-2022 the original author or authors.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.springframework.orm.jpa;
+
+import org.springframework.aot.hint.RuntimeHints;
+import org.springframework.aot.hint.RuntimeHintsRegistrar;
+import org.springframework.aot.hint.TypeReference;
+import org.springframework.util.ClassUtils;
+
+/**
+ * {@link RuntimeHintsRegistrar} implementation that makes sure JDK proxy hints related to
+ * {@link AbstractEntityManagerFactoryBean} are registered.
+ *
+ * @author Sebastien Deleuze
+ * @since 6.0
+ */
+class EntityManagerRuntimeHints implements RuntimeHintsRegistrar {
+
+	private static final String HIBERNATE_SESSION_FACTORY_CLASS_NAME = "org.hibernate.SessionFactory";
+
+	@Override
+	public void registerHints(RuntimeHints hints, ClassLoader classLoader) {
+		if (ClassUtils.isPresent(HIBERNATE_SESSION_FACTORY_CLASS_NAME, classLoader)) {
+			hints.proxies().registerJdkProxy(TypeReference.of(HIBERNATE_SESSION_FACTORY_CLASS_NAME),
+					TypeReference.of(EntityManagerFactoryInfo.class));
+			hints.proxies().registerJdkProxy(TypeReference.of("org.hibernate.Session"),
+					TypeReference.of(EntityManagerProxy.class));
+		}
+	}
+}
diff --git a/spring-orm/src/main/resources/META-INF/spring/aot.factories b/spring-orm/src/main/resources/META-INF/spring/aot.factories
index 4b2e8097817..e8ba1dea986 100644
--- a/spring-orm/src/main/resources/META-INF/spring/aot.factories
+++ b/spring-orm/src/main/resources/META-INF/spring/aot.factories
@@ -1,2 +1,5 @@
 org.springframework.beans.factory.aot.BeanRegistrationAotProcessor=\
 org.springframework.orm.jpa.persistenceunit.PersistenceManagedTypesBeanRegistrationAotProcessor
+
+org.springframework.aot.hint.RuntimeHintsRegistrar=\
+org.springframework.orm.jpa.EntityManagerRuntimeHints
diff --git a/spring-orm/src/test/java/org/springframework/orm/jpa/EntityManagerRuntimeHintsTests.java b/spring-orm/src/test/java/org/springframework/orm/jpa/EntityManagerRuntimeHintsTests.java
new file mode 100644
index 00000000000..b14c3e4db5b
--- /dev/null
+++ b/spring-orm/src/test/java/org/springframework/orm/jpa/EntityManagerRuntimeHintsTests.java
@@ -0,0 +1,59 @@
+/*
+ * Copyright 2002-2022 the original author or authors.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.springframework.orm.jpa;
+
+import org.hibernate.Session;
+import org.hibernate.SessionFactory;
+import org.junit.jupiter.api.BeforeEach;
+import org.junit.jupiter.api.Test;
+
+import org.springframework.aot.hint.RuntimeHints;
+import org.springframework.aot.hint.RuntimeHintsRegistrar;
+import org.springframework.aot.hint.predicate.RuntimeHintsPredicates;
+import org.springframework.beans.factory.aot.AotServices;
+import org.springframework.util.ClassUtils;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+/**
+ * Tests for {@link EntityManagerRuntimeHints}.
+ *
+ * @author Sebastien Deleuze
+ */
+class EntityManagerRuntimeHintsTests {
+
+	private final RuntimeHints hints = new RuntimeHints();
+
+	@BeforeEach
+	void setup() {
+		AotServices.factories().load(RuntimeHintsRegistrar.class)
+				.forEach(registrar -> registrar.registerHints(this.hints,
+						ClassUtils.getDefaultClassLoader()));
+	}
+
+	@Test
+	void entityManagerFactoryInfoHasHibernateHints() {
+		assertThat(RuntimeHintsPredicates.proxies().forInterfaces(SessionFactory.class, EntityManagerFactoryInfo.class))
+				.accepts(this.hints);
+	}
+
+	@Test
+	void entityManagerProxyHasHibernateHints() {
+		assertThat(RuntimeHintsPredicates.proxies().forInterfaces(Session.class, EntityManagerProxy.class))
+				.accepts(this.hints);
+	}
+}