diff --git a/spring-messaging/src/main/java/org/springframework/messaging/handler/invocation/ReactiveReturnValueHandler.java b/spring-messaging/src/main/java/org/springframework/messaging/handler/invocation/ReactiveReturnValueHandler.java
index 3fdd678d575..ac3ca100196 100644
--- a/spring-messaging/src/main/java/org/springframework/messaging/handler/invocation/ReactiveReturnValueHandler.java
+++ b/spring-messaging/src/main/java/org/springframework/messaging/handler/invocation/ReactiveReturnValueHandler.java
@@ -22,11 +22,12 @@ import org.springframework.core.MethodParameter;
 import org.springframework.core.ReactiveAdapter;
 import org.springframework.core.ReactiveAdapterRegistry;
 import org.springframework.messaging.support.MonoToListenableFutureAdapter;
+import org.springframework.util.Assert;
 import org.springframework.util.concurrent.ListenableFuture;
 
 /**
- * Support for single-value reactive types (like {@code Mono} or {@code Single}) as a
- * return value type.
+ * Support for single-value reactive types (like {@code Mono} or {@code Single})
+ * as a return value type.
  *
  * @author Sebastien Deleuze
  * @since 5.1
@@ -53,12 +54,13 @@ public class ReactiveReturnValueHandler extends AbstractAsyncReturnValueHandler
 	@Override
 	public boolean isAsyncReturnValue(Object returnValue, MethodParameter returnType) {
 		ReactiveAdapter adapter = this.adapterRegistry.getAdapter(returnType.getParameterType(), returnValue);
-		return !adapter.isMultiValue() && !adapter.isNoValue();
+		return (adapter != null && !adapter.isMultiValue() && !adapter.isNoValue());
 	}
 
 	@Override
 	public ListenableFuture<?> toListenableFuture(Object returnValue, MethodParameter returnType) {
 		ReactiveAdapter adapter = this.adapterRegistry.getAdapter(returnType.getParameterType(), returnValue);
+		Assert.state(adapter != null, () -> "No ReactiveAdapter found for " + returnType.getParameterType());
 		return new MonoToListenableFutureAdapter<>(Mono.from(adapter.toPublisher(returnValue)));
 	}
 
diff --git a/spring-web/src/main/java/org/springframework/http/client/OkHttp3ClientHttpRequestFactory.java b/spring-web/src/main/java/org/springframework/http/client/OkHttp3ClientHttpRequestFactory.java
index 59c4f7e0591..894a3f675b5 100644
--- a/spring-web/src/main/java/org/springframework/http/client/OkHttp3ClientHttpRequestFactory.java
+++ b/spring-web/src/main/java/org/springframework/http/client/OkHttp3ClientHttpRequestFactory.java
@@ -21,6 +21,7 @@ import java.net.MalformedURLException;
 import java.net.URI;
 import java.util.concurrent.TimeUnit;
 
+import okhttp3.Cache;
 import okhttp3.OkHttpClient;
 import okhttp3.Request;
 import okhttp3.RequestBody;
@@ -118,8 +119,9 @@ public class OkHttp3ClientHttpRequestFactory
 	public void destroy() throws IOException {
 		if (this.defaultClient) {
 			// Clean up the client if we created it in the constructor
-			if (this.client.cache() != null) {
-				this.client.cache().close();
+			Cache cache = this.client.cache();
+			if (cache != null) {
+				cache.close();
 			}
 			this.client.dispatcher().executorService().shutdown();
 		}