diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
index c5d9e11624b..75f932757f2 100644
--- a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessor.java
@@ -865,7 +865,7 @@ public class AutowiredAnnotationBeanPostProcessor implements SmartInstantiationA
 				descriptors[i] = currDesc;
 				try {
 					Object arg = beanFactory.resolveDependency(currDesc, beanName, autowiredBeanNames, typeConverter);
-					if (arg == null && !this.required) {
+					if (arg == null && !this.required && !methodParam.isOptional()) {
 						arguments = null;
 						break;
 					}
diff --git a/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
index f76705de4af..8340fcfdeeb 100644
--- a/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
+++ b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/AutowiredAnnotationBeanPostProcessorTests.java
@@ -32,6 +32,7 @@ import java.util.LinkedHashMap;
 import java.util.LinkedHashSet;
 import java.util.List;
 import java.util.Map;
+import java.util.Optional;
 import java.util.Properties;
 import java.util.Set;
 import java.util.SortedMap;
@@ -2600,6 +2601,26 @@ public class AutowiredAnnotationBeanPostProcessorTests {
 		assertThat(bean.testBean).isSameAs(bf.getBean("annotatedBean"));
 	}
 
+	@Test
+	public void testMethodInjectionWithMultiMixedNullableArgs(){
+		bf.registerBeanDefinition("nonNullBean", new RootBeanDefinition(
+				NonNullBean.class));
+		bf.registerBeanDefinition("mixedNullableInjectionBean", new RootBeanDefinition(MixedNullableInjectionBean.class));
+		MixedNullableInjectionBean mixedNullableInjectionBean = bf.getBean(MixedNullableInjectionBean.class);
+		assertThat(mixedNullableInjectionBean.nonNullBean).isNotNull();
+		assertThat(mixedNullableInjectionBean.nullableBean).isNull();
+	}
+
+	@Test
+	public void testMethodInjectionWithMultiMixedOptionalArgs(){
+		bf.registerBeanDefinition("nonNullBean", new RootBeanDefinition(
+				NonNullBean.class));
+		bf.registerBeanDefinition("mixedOptionalInjectionBean", new RootBeanDefinition(MixedOptionalInjectionBean.class));
+		MixedOptionalInjectionBean mixedOptionalInjectionBean = bf.getBean(MixedOptionalInjectionBean.class);
+		assertThat(mixedOptionalInjectionBean.nonNullBean).isNotNull();
+		assertThat(mixedOptionalInjectionBean.nullableBean).isNull();
+	}
+
 	private <E extends UnsatisfiedDependencyException> Consumer<E> methodParameterDeclaredOn(
 			Class<?> expected) {
 		return declaredOn(
@@ -4346,4 +4367,35 @@ public class AutowiredAnnotationBeanPostProcessorTests {
 		}
 	}
 
+	static class NullableBean {
+
+	}
+	static class NonNullBean {
+
+	}
+
+	static class MixedNullableInjectionBean{
+		public NonNullBean nonNullBean;
+		public NullableBean nullableBean;
+
+		@Autowired(required = false)
+		public void nullabilityInjection(@Nullable NullableBean nullableBean, NonNullBean nonNullBean){
+			if(nullableBean != null){
+				this.nullableBean = nullableBean;
+			}
+			this.nonNullBean = nonNullBean;
+		}
+	}
+
+	static class MixedOptionalInjectionBean{
+		public NonNullBean nonNullBean;
+		public NullableBean nullableBean;
+
+		@Autowired(required = false)
+		public void optionalInjection(Optional<NullableBean> optionalBean, NonNullBean nonNullBean){
+			optionalBean.ifPresent(bean -> this.nullableBean = bean);
+			this.nonNullBean = nonNullBean;
+		}
+	}
+
 }