diff --git a/spring-beans/src/main/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHints.java b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHints.java
new file mode 100644
index 00000000000..0239d42d7df
--- /dev/null
+++ b/spring-beans/src/main/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHints.java
@@ -0,0 +1,41 @@
+/*
+ * Copyright 2002-2022 the original author or authors.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.springframework.beans.factory.annotation;
+
+import java.util.stream.Stream;
+
+import org.springframework.aot.hint.RuntimeHints;
+import org.springframework.aot.hint.RuntimeHintsRegistrar;
+import org.springframework.util.ClassUtils;
+
+/**
+ * {@link RuntimeHintsRegistrar} for Jakarta annotations.
+ * <p>Hints are only registered if Jakarta inject is on the classpath.
+ *
+ * @author Brian Clozel
+ */
+class JakartaAnnotationsRuntimeHints implements RuntimeHintsRegistrar {
+
+	@Override
+	public void registerHints(RuntimeHints hints, ClassLoader classLoader) {
+		if (ClassUtils.isPresent("jakarta.inject.Inject", classLoader)) {
+			Stream.of("jakarta.inject.Inject", "jakarta.inject.Qualifier").forEach(annotationType ->
+					hints.reflection().registerType(ClassUtils.resolveClassName(annotationType, classLoader)));
+		}
+	}
+
+}
diff --git a/spring-beans/src/main/resources/META-INF/spring/aot.factories b/spring-beans/src/main/resources/META-INF/spring/aot.factories
index b96644577c1..c68e89fda2f 100644
--- a/spring-beans/src/main/resources/META-INF/spring/aot.factories
+++ b/spring-beans/src/main/resources/META-INF/spring/aot.factories
@@ -1,5 +1,6 @@
 org.springframework.aot.hint.RuntimeHintsRegistrar=\
-org.springframework.beans.factory.annotation.BeanFactoryAnnotationsRuntimeHints
+org.springframework.beans.factory.annotation.BeanFactoryAnnotationsRuntimeHints,\
+org.springframework.beans.factory.annotation.JakartaAnnotationsRuntimeHints
 
 org.springframework.beans.factory.aot.BeanFactoryInitializationAotProcessor=\
 org.springframework.beans.factory.aot.BeanRegistrationsAotProcessor
diff --git a/spring-beans/src/test/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHintsTests.java b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHintsTests.java
new file mode 100644
index 00000000000..d56b851f93f
--- /dev/null
+++ b/spring-beans/src/test/java/org/springframework/beans/factory/annotation/JakartaAnnotationsRuntimeHintsTests.java
@@ -0,0 +1,59 @@
+/*
+ * Copyright 2002-2022 the original author or authors.
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.springframework.beans.factory.annotation;
+
+
+import jakarta.inject.Inject;
+import jakarta.inject.Qualifier;
+import org.junit.jupiter.api.BeforeEach;
+import org.junit.jupiter.api.Test;
+
+import org.springframework.aot.hint.RuntimeHints;
+import org.springframework.aot.hint.RuntimeHintsRegistrar;
+import org.springframework.aot.hint.predicate.RuntimeHintsPredicates;
+import org.springframework.beans.factory.aot.AotServices;
+import org.springframework.util.ClassUtils;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+/**
+ * Tests for {@link JakartaAnnotationsRuntimeHints}.
+ *
+ * @author Brian Clozel
+ */
+class JakartaAnnotationsRuntimeHintsTests {
+
+	private final RuntimeHints hints = new RuntimeHints();
+
+	@BeforeEach
+	void setup() {
+		AotServices.factories().load(RuntimeHintsRegistrar.class)
+				.forEach(registrar -> registrar.registerHints(this.hints,
+						ClassUtils.getDefaultClassLoader()));
+	}
+
+	@Test
+	void jakartaInjectAnnotationHasHints() {
+		assertThat(RuntimeHintsPredicates.reflection().onType(Inject.class)).accepts(this.hints);
+	}
+
+	@Test
+	void jakartaQualifierAnnotationHasHints() {
+		assertThat(RuntimeHintsPredicates.reflection().onType(Qualifier.class)).accepts(this.hints);
+	}
+
+}
diff --git a/spring-context/spring-context.gradle b/spring-context/spring-context.gradle
index b038d428927..72c93322f8a 100644
--- a/spring-context/spring-context.gradle
+++ b/spring-context/spring-context.gradle
@@ -1,3 +1,7 @@
+plugins {
+	id 'org.springframework.build.runtimehints-agent'
+}
+
 description = "Spring Context"
 
 apply plugin: "kotlin"