diff --git a/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java b/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
index 87b2b6f0a25..13b2f43d0c2 100644
--- a/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
+++ b/spring-jdbc/src/main/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslator.java
@@ -95,7 +95,9 @@ public class SQLStateSQLExceptionTranslator extends AbstractFallbackSQLException
 			301,   // SAP HANA
 			1062,  // MySQL/MariaDB
 			2601,  // MS SQL Server
-			2627   // MS SQL Server
+			2627,  // MS SQL Server
+			-239,  // Informix
+			-268   // Informix
 		);
 
 
diff --git a/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java b/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
index 71820d7259d..1bce4f41c03 100644
--- a/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
+++ b/spring-jdbc/src/test/java/org/springframework/jdbc/support/SQLStateSQLExceptionTranslatorTests.java
@@ -90,6 +90,16 @@ class SQLStateSQLExceptionTranslatorTests {
 		assertTranslation("23000", 301, DuplicateKeyException.class);
 	}
 
+	@Test
+	void translateDuplicateKeyInformix1() {
+		assertTranslation("23000", -239, DuplicateKeyException.class);
+	}
+
+	@Test
+	void translateDuplicateKeyInformix2() {
+		assertTranslation("23000", -268, DuplicateKeyException.class);
+	}
+
 	@Test
 	void translateDataAccessResourceFailure() {
 		assertTranslation("53", DataAccessResourceFailureException.class);
diff --git a/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java b/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
index 162d5c2e6c5..5a8cc34992f 100644
--- a/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
+++ b/spring-r2dbc/src/main/java/org/springframework/r2dbc/connection/ConnectionFactoryUtils.java
@@ -76,7 +76,9 @@ public abstract class ConnectionFactoryUtils {
 			301,   // SAP HANA
 			1062,  // MySQL/MariaDB
 			2601,  // MS SQL Server
-			2627   // MS SQL Server
+			2627,  // MS SQL Server
+			-239,  // Informix
+			-268   // Informix
 		);
 
 
diff --git a/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java b/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
index 49861f0a4e8..cd4fb8c91d8 100644
--- a/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
+++ b/spring-r2dbc/src/test/java/org/springframework/r2dbc/connection/ConnectionFactoryUtilsTests.java
@@ -16,6 +16,8 @@
 
 package org.springframework.r2dbc.connection;
 
+import java.util.List;
+
 import io.r2dbc.spi.R2dbcBadGrammarException;
 import io.r2dbc.spi.R2dbcDataIntegrityViolationException;
 import io.r2dbc.spi.R2dbcException;
@@ -25,6 +27,9 @@ import io.r2dbc.spi.R2dbcRollbackException;
 import io.r2dbc.spi.R2dbcTimeoutException;
 import io.r2dbc.spi.R2dbcTransientResourceException;
 import org.junit.jupiter.api.Test;
+import org.junit.jupiter.params.ParameterizedTest;
+import org.junit.jupiter.params.provider.Arguments;
+import org.junit.jupiter.params.provider.FieldSource;
 
 import org.springframework.dao.CannotAcquireLockException;
 import org.springframework.dao.DataAccessResourceFailureException;
@@ -38,6 +43,7 @@ import org.springframework.r2dbc.BadSqlGrammarException;
 import org.springframework.r2dbc.UncategorizedR2dbcException;
 
 import static org.assertj.core.api.Assertions.assertThat;
+import static org.junit.jupiter.params.provider.Arguments.arguments;
 
 /**
  * Tests for {@link ConnectionFactoryUtils}.
@@ -91,30 +97,25 @@ class ConnectionFactoryUtilsTests {
 		Exception exception = ConnectionFactoryUtils.convertR2dbcException("", "",
 				new R2dbcDataIntegrityViolationException());
 		assertThat(exception).isExactlyInstanceOf(DataIntegrityViolationException.class);
+	}
 
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23505"));
-		assertThat(exception).isExactlyInstanceOf(DuplicateKeyException.class);
+	static final List<Arguments> duplicateKeyErrorCodes = List.of(
+			arguments("Oracle", "23505", 0),
+			arguments("Oracle", "23000", 1),
+			arguments("SAP HANA", "23000", 301),
+			arguments("MySQL/MariaDB", "23000", 1062),
+			arguments("MS SQL Server", "23000", 2601),
+			arguments("MS SQL Server", "23000", 2627),
+			arguments("Informix", "23000", -239),
+			arguments("Informix", "23000", -268)
+		);
 
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 1));
-		assertThat(exception).as("Oracle").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 301));
-		assertThat(exception).as("SAP HANA").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 1062));
-		assertThat(exception).as("MySQL/MariaDB").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 2601));
-		assertThat(exception).as("MS SQL Server").isExactlyInstanceOf(DuplicateKeyException.class);
-
-		exception = ConnectionFactoryUtils.convertR2dbcException("", "",
-				new R2dbcDataIntegrityViolationException("reason", "23000", 2627));
-		assertThat(exception).as("MS SQL Server").isExactlyInstanceOf(DuplicateKeyException.class);
+	@ParameterizedTest
+	@FieldSource("duplicateKeyErrorCodes")
+	void shouldTranslateIntegrityViolationExceptionToDuplicateKeyException(String db, String sqlState, int errorCode) {
+		Exception exception = ConnectionFactoryUtils.convertR2dbcException("", "",
+				new R2dbcDataIntegrityViolationException("reason", sqlState, errorCode));
+		assertThat(exception).as(db).isExactlyInstanceOf(DuplicateKeyException.class);
 	}
 
 	@Test
@@ -135,24 +136,27 @@ class ConnectionFactoryUtilsTests {
 	void messageGeneration() {
 		Exception exception = ConnectionFactoryUtils.convertR2dbcException("TASK",
 				"SOME-SQL", new R2dbcTransientResourceException("MESSAGE"));
-		assertThat(exception).isExactlyInstanceOf(
-				TransientDataAccessResourceException.class).hasMessage("TASK; SQL [SOME-SQL]; MESSAGE");
+		assertThat(exception)
+				.isExactlyInstanceOf(TransientDataAccessResourceException.class)
+				.hasMessage("TASK; SQL [SOME-SQL]; MESSAGE");
 	}
 
 	@Test
 	void messageGenerationNullSQL() {
 		Exception exception = ConnectionFactoryUtils.convertR2dbcException("TASK", null,
 				new R2dbcTransientResourceException("MESSAGE"));
-		assertThat(exception).isExactlyInstanceOf(
-				TransientDataAccessResourceException.class).hasMessage("TASK; MESSAGE");
+		assertThat(exception)
+				.isExactlyInstanceOf(TransientDataAccessResourceException.class)
+				.hasMessage("TASK; MESSAGE");
 	}
 
 	@Test
 	void messageGenerationNullMessage() {
 		Exception exception = ConnectionFactoryUtils.convertR2dbcException("TASK",
 				"SOME-SQL", new R2dbcTransientResourceException());
-		assertThat(exception).isExactlyInstanceOf(
-				TransientDataAccessResourceException.class).hasMessage("TASK; SQL [SOME-SQL]; null");
+		assertThat(exception)
+				.isExactlyInstanceOf(TransientDataAccessResourceException.class)
+				.hasMessage("TASK; SQL [SOME-SQL]; null");
 	}