diff --git a/packages/runtime-core/__tests__/apiCreateApp.spec.ts b/packages/runtime-core/__tests__/apiCreateApp.spec.ts
index e5e9a5906..3fb5bb175 100644
--- a/packages/runtime-core/__tests__/apiCreateApp.spec.ts
+++ b/packages/runtime-core/__tests__/apiCreateApp.spec.ts
@@ -30,6 +30,11 @@ describe('api: createApp', () => {
     const root1 = nodeOps.createElement('div')
     createApp(Comp).mount(root1)
     expect(serializeInner(root1)).toBe(`0`)
+    //#5571 mount multiple apps to the same host element
+    createApp(Comp).mount(root1)
+    expect(
+      `There is already an app instance mounted on the host container`
+    ).toHaveBeenWarned()
 
     // mount with props
     const root2 = nodeOps.createElement('div')
diff --git a/packages/runtime-core/src/apiCreateApp.ts b/packages/runtime-core/src/apiCreateApp.ts
index 6b2093141..b0c8a3f2b 100644
--- a/packages/runtime-core/src/apiCreateApp.ts
+++ b/packages/runtime-core/src/apiCreateApp.ts
@@ -284,6 +284,14 @@ export function createAppAPI<HostElement>(
         isSVG?: boolean
       ): any {
         if (!isMounted) {
+          // #5571
+          if (__DEV__ && (rootContainer as any).__vue_app__) {
+            warn(
+              `There is already an app instance mounted on the host container.\n` +
+                ` If you want to mount another app on the same host container,` +
+                ` you need to unmount the previous app by calling \`app.unmount()\` first.`
+            )
+          }
           const vnode = createVNode(
             rootComponent as ConcreteComponent,
             rootProps