diff --git a/packages/compiler-sfc/__tests__/compileScript.spec.ts b/packages/compiler-sfc/__tests__/compileScript.spec.ts
index 11b5661c1..4eeeb1cf2 100644
--- a/packages/compiler-sfc/__tests__/compileScript.spec.ts
+++ b/packages/compiler-sfc/__tests__/compileScript.spec.ts
@@ -1143,6 +1143,36 @@ describe('SFC analyze <script> bindings', () => {
     })
   })
 
+  it('recognizes data/setup return', () => {
+    const { bindings } = compile(`
+      <script>
+        const bar = 2
+        const foo = 2
+        const msg = 2
+        const hello = 2
+        export default {
+          setup() {
+            return {
+              foo: 1,
+              hello: numm
+            }
+          },
+          data() {
+            return {
+              foo: null,
+              msg: null
+            }
+          }
+        }
+      </script>
+    `)
+    expect(bindings).toStrictEqual({
+      foo: BindingTypes.SETUP_MAYBE_REF,
+      msg: BindingTypes.DATA,
+      hello: BindingTypes.SETUP_MAYBE_REF,
+    })
+  })
+
   it('recognizes methods', () => {
     const { bindings } = compile(`
       <script>
diff --git a/packages/compiler-sfc/src/script/analyzeScriptBindings.ts b/packages/compiler-sfc/src/script/analyzeScriptBindings.ts
index ae544f640..adede0911 100644
--- a/packages/compiler-sfc/src/script/analyzeScriptBindings.ts
+++ b/packages/compiler-sfc/src/script/analyzeScriptBindings.ts
@@ -87,6 +87,8 @@ function analyzeBindingsFromOptions(node: ObjectExpression): BindingMetadata {
           bodyItem.argument.type === 'ObjectExpression'
         ) {
           for (const key of getObjectExpressionKeys(bodyItem.argument)) {
+            // use variables in setup first, consistent with runtime
+            if (bindings[key] === BindingTypes.SETUP_MAYBE_REF) continue
             bindings[key] =
               property.key.name === 'setup'
                 ? BindingTypes.SETUP_MAYBE_REF
diff --git a/packages/runtime-core/apiMixed.spec.ts b/packages/runtime-core/apiMixed.spec.ts
new file mode 100644
index 000000000..3f8267819
--- /dev/null
+++ b/packages/runtime-core/apiMixed.spec.ts
@@ -0,0 +1,86 @@
+import { defineComponent, h, renderToString } from '@vue/runtime-test'
+
+describe('api: options', () => {
+  test('mix api options: setup and data with created', () => {
+    const mixinA = defineComponent({
+      setup() {
+        return {
+          a: 'from setup',
+        }
+      },
+      data() {
+        return {
+          a: 'from data',
+        }
+      },
+      created(this: any) {
+        this.a = 'from created'
+      },
+      render() {
+        return `${this.a}`
+      },
+    })
+    expect(renderToString(h(mixinA))).toBe(`from created`)
+  })
+
+  test('mix api options: data and setup with created', () => {
+    const mixinA = defineComponent({
+      data() {
+        return {
+          a: 'from data',
+        }
+      },
+      setup() {
+        return {
+          a: 'from setup',
+        }
+      },
+      created(this: any) {
+        this.a = 'from created'
+      },
+      render() {
+        return `${this.a}`
+      },
+    })
+    expect(renderToString(h(mixinA))).toBe(`from created`)
+  })
+
+  test('mix api options: data and setup', () => {
+    const mixinA = defineComponent({
+      data() {
+        return {
+          a: 'from data',
+        }
+      },
+      setup() {
+        return {
+          a: 'from setup',
+        }
+      },
+      created(this: any) {},
+      render() {
+        return `${this.a}`
+      },
+    })
+    expect(renderToString(h(mixinA))).toBe(`from setup`)
+  })
+
+  test('mix api options: setup and data', () => {
+    const mixinA = defineComponent({
+      setup() {
+        return {
+          a: 'from setup',
+        }
+      },
+      data() {
+        return {
+          a: 'from data',
+        }
+      },
+      render() {
+        return `${this.a}`
+      },
+    })
+    expect(renderToString(h(mixinA))).toBe(`from setup`)
+  })
+})